Uworld | Step 1

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Uworld | Step 1

27 Nov, 19:00

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Uworld | Step 1

10 Nov, 12:50

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933 0 0

Uworld | Step 1

26 May 2023, 19:52

Educational objective: Lesions of the jugular foramen can result in jugular foramen (Vernet) syndrome, which is characterized by the dysfunction of cranial nerves IX, X, and XI. Symptoms include dysphagia, hoarseness, loss of gag reflex on the ipsilateral side, and deviation of the uvula toward the normal side.

12k 0 4

Uworld | Step 1

26 May 2023, 12:51

A lesion involving which of the following anatomical structures is most likely responsible for this patient's symptoms?

Опрос

A. Cerebellopontine angle
B. Foramen magnum
C.Foramen ovale
D.Foramen rotundum
E. Hypoglossal canal
F. Jugular foramen

751 голосов

11.5k 0 7

Uworld | Step 1

26 May 2023, 12:51

A 67-year-old woman with a known history of lung cancer comes to the office due to hoarseness and
difficulty swallowing. She has no disturbances in vision or hearing. On examination, there is loss of the gag reflex on the left side; when the patient is prompted to say "ah," the uvula deviates to the right side.
a right lower lobe lung mass and several osteolytic rib lesions. MRI of the head also demonstrates multiple Her left shoulder is drooped and strength is reduced during left shoulder shrug testing. Chest x-ray shows
lesions consistent with metastasis.

9.8k 0 3

Uworld | Step 1

21 May 2023, 23:03

Educational objective: Tay-Sachs disease is an autosomal recessive disorder caused by [3-hexosaminidase A deficiency, which results in GM2 ganglioside accumulation. Key clinical features include progressive neurodegeneration and a cherry-red macular spot. In contrast to patients with Niemann-Pick disease, those with Tay Sachs disease have no hepatosplenomegaly.

8.9k 0 1

Uworld | Step 1

21 May 2023, 18:02

Accumulation of which of the following metabolites is most likely present in this patient's tissues?

Опрос

A. Galactocerebroside
B. Globotriaosylceramide
C. Glucocerebroside
D.Glycogen
E. GM2 ganglioside
F. Heparan sulfate
G .Sphingomyelin

596 голосов

8.8k 0 5

Uworld | Step 1

21 May 2023, 18:01

An 8-month-old girl is brought to the office for evaluation of irritability and regression of motor skills. Her birth was unremarkable and she appeared to develop normally, but she can no longer sit or roll over. Her parents have also noticed that she startles easily with loud noises. Head circumference measurement is consistent with macrocephaly. Bilateral funduscopic evaluation shows a bright red fovea centralis that is surrounded by a contrasting white macula. Peripheral vision is decreased. Abdominal examination is normal.

7.8k 0 3

Uworld | Step 1

21 May 2023, 17:52

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5.7k 0 11

Uworld | Step 1

20 May 2023, 22:16

Educational objective: Neisseria meningitidis can cause sepsis and circulatory collapse in previously healthy young individuals. Lipooligosaccharide, a virulence factor in the pathogens outer membrane, is the major underlying cause of disease severity.

5.8k 0 1

Uworld | Step 1

20 May 2023, 18:18

Which of the following microbial components is directly responsible for the severity of disease in this patient?

Опрос

A. Capsular polysaccharide
B. lmmunoglobulin protease
C. Lipo-oligosaccharide
D.Lipoteichoic acid
E. Superantigen exotoxin

514 голосов

6.4k 0 2

Uworld | Step 1

20 May 2023, 18:15

A 16-year-old girl is brought to the emergency department after she became unresponsive. Temperature is 39.7 C (103.5 F), blood pressure is 70/40 mm Hg, and pulse is 130/min and thready. There is a diffuse petechial and ecchymotic skin rash. Laboratory testing reveals leukocytosis with left shift and evidence of disseminated intravascular coagulation and multiorgan failure. Despite aggressive interventions, the patient dies several hours after admission. Autopsy reveals hemorrhagic necrosis of many internal organs, including the bilateral adrenal glands.

6.2k 0 2

Uworld | Step 1

4 May 2023, 23:59

Educational objective: Amyotrophic lateral sclerosis (ALS) causes both upper and lower motor neuron lesions. Loss of neurons of the anterior horns of the spinal cord (LMN lesion) causes muscle weakness and atrophy. Demyelination of the lateral corticospinal tract (UMN lesion) leads to spasticity and hyperretlexia.

7.3k 0 3

Uworld | Step 1

4 May 2023, 23:26

The patient most likely suffered from which of the following?

Опрос

A. Amyotrophic lateral sclerosis
B. Poliomyelitis
C.Rabies
D.Huntington disease
E. Friedreich ataxia
F. Vitamin 812 deficiency

505 голосов

7k 0 2

Uworld | Step 1

4 May 2023, 23:26

A Caucasian male who suffers from a severe neurological disease dies of an overwhelming respiratory infection. Autopsy shows an atrophic precentral gyrus and thin anterior roots of the spinal cord. Light microscopy reveals a severe loss of neurons in the anterior horn of the spinal cord and in the hypoglossal and ambiguous cranial nerve nuclei; corticospinal tracts stain only faintly, indicating demyelinization.

5.5k 0 2

Uworld | Step 1

30 Apr 2023, 18:59

Educational Objective: Vitamin A overuse can result in intracranial hypertension, skin changes and hepatosplenomegaly.

5.4k 0 2

Uworld | Step 1

30 Apr 2023, 08:59

Which of the following is a likely cause of this patient's condition?

Опрос

A. Thiamine deficiency
B. Niacin deficiency
C. Vitamin B,2 deficiency
D.Riboflavin deficiency
E. Vitamin C overuse
F. Vitamin E overuse
G.Vitamin A overuse

582 голосов

5.4k 0 4

Uworld | Step 1

30 Apr 2023, 08:58

A 35-year-old female is hospitalized with headaches and vomiting. She has a long history of psychiatric illness and is known to practice eccentric dietary habits. Physical findings include papilledema, dry skin and hepatosplenomegaly. Head CT scan is ordered immediately but is negative for intracranial mass.

4.9k 0 3

Uworld | Step 1

29 Apr 2023, 18:58

Educational objective: Local anesthetics diffuse through the neuronal cell membrane to block the influx of sodium into the cell. This prevents depolarization and inhibits action potential propagation.

4.9k 0 2

Uworld | Step 1

29 Apr 2023, 08:58

These effects are most likely due to which of the following changes within the affected neurons?

Опрос

A. Blockade of potassium channels
B. Blockade of sodium channels
C.Decreased calcium current
D.lncreased chloride conductance
E. Interruption of axonal transport

428 голосов

4.9k 0 1

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