Educational objective: The pathogenesis of migraines is complex and multifactorial but includes neurogenic inflammation, vasodilation, and sensitization of trigeminal afferents in the meninges. Triptans are serotonin 5-hydroxytryptamine 18/1 D agonists that stimulate the trigeminovascular serotonin receptors, resulting in inhibition of vasoactive peptide release, intracranial vasoconstriction, and decreased pain. They are used as abortive therapy for acute migraine.