KB5043145, the most recent optional update for Windows 11 to date,
causes multiple issues for many users. The most serious one is a blue screen of death that makes the PC unbootable. Microsoft has confirmed the bug and is working on a solution.
After upgrading the device to Windows 11 OS Build 22621.4249, a number of users faced the inability to start the computer. The only solution that was of help for them is to uninstall the update from the recovery environment.
Sometimes, the bug makes Windows 11 to start into the BitLocker recover environment, especially after several failed recovery attempts.
Among the mentioned BSOD issues, users also report that the same update may prevent USB ports from working. As most modern peripheral devices connect via USB, this breaks them. Keyboards, mouses, and webcam stop working. The latter issue mainly affects N6005 and N5105 Intel NUCs, and Asus TUF / ROG laptops, and other gaming products from the same vendor.
If you are affected - then uninstall the buggy update: wusa.exe /uninstall /kb:5043145. Run the
command from WinRE.